Which of the following is the largest white-matter commissure in the brain?

Which of the following is the largest white-matter commissure in the brain?

• A. Anterior commissure
• B. Corpus callosum
• C. Posterior commissure
• D. Hippocampal commissure

Answer: (B)

The main concept here is interhemispheric communication through white-matter connections. The corpus callosum is a broad, continuous bundle of myelinated axons that spans the two cerebral hemispheres, making it the primary conduit for signals between left and right sides. It links many different cortical areas across the midline, from frontal to occipital regions, and contains far more fibers than any other commissure. Because of its size and widespread connections, it dwarfs the other commissures—such as the anterior commissure (which mainly connects parts of the temporal lobes), the posterior commissure (smaller and involved in more specific midline pathways), and the hippocampal commissure (a minor connection within the hippocampal formation). This makes the corpus callosum the largest white-matter commissure in the brain.

The main concept here is interhemispheric communication through white-matter connections. The corpus callosum is a broad, continuous bundle of myelinated axons that spans the two cerebral hemispheres, making it the primary conduit for signals between left and right sides. It links many different cortical areas across the midline, from frontal to occipital regions, and contains far more fibers than any other commissure. Because of its size and widespread connections, it dwarfs the other commissures—such as the anterior commissure (which mainly connects parts of the temporal lobes), the posterior commissure (smaller and involved in more specific midline pathways), and the hippocampal commissure (a minor connection within the hippocampal formation). This makes the corpus callosum the largest white-matter commissure in the brain.